Roles of fibroblast growth factor receptors in carcinogenesis
EM Haugsten, A Wiedlocha, S Olsnes… - Molecular cancer research, 2010 - AACR
The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …
FGF19–FGFR4 Signaling in Hepatocellular Carcinoma
A Raja, I Park, F Haq, SM Ahn - Cells, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an
increasing mortality rate. Aberrant expression of fibroblast growth factor 19–fibroblast growth …
increasing mortality rate. Aberrant expression of fibroblast growth factor 19–fibroblast growth …
FGF23 from bench to bedside
CP Kovesdy, LD Quarles - American Journal of Physiology …, 2016 - journals.physiology.org
There is a strong association between elevated circulating fibroblast growth factor-23
(FGF23) levels and adverse outcomes in patients with chronic kidney disease (CKD) of all …
(FGF23) levels and adverse outcomes in patients with chronic kidney disease (CKD) of all …
FGF19 and cancer
BC Lin, LR Desnoyers - Endocrine FGFs and Klothos, 2012 - Springer
Fibroblast growth factors (FGFs) and their cognate receptors, FGF receptors (FGFRs), play
critical roles in a variety of normal developmental and physiological processes. Numerous …
critical roles in a variety of normal developmental and physiological processes. Numerous …
Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1
A Rohrbeck, J Borlak - PloS one, 2009 - journals.plos.org
Background Lung cancer is a leading cause of cancer morbidity. To improve an
understanding of molecular causes of disease a transgenic mouse model was investigated …
understanding of molecular causes of disease a transgenic mouse model was investigated …
Differential Effects of Polymorphic Alleles of FGF Receptor 4 on Colon Cancer Growth and Metastasis
C Heinzle, A Gsur, M Hunjadi, Z Erdem, C Gauglhofer… - Cancer research, 2012 - AACR
A gly388arg polymorphism (rs351855) in the transmembrane domain of the fibroblast
growth factor receptor (FGFR4) is associated with increased risk, staging, and metastasis in …
growth factor receptor (FGFR4) is associated with increased risk, staging, and metastasis in …
Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?
C Heinzle, Z Erdem, J Paur… - Current …, 2014 - ingentaconnect.com
Fibroblast growth factors (FGF) and their tyrosine kinase receptors (FGFR) support cell
proliferation, survival and migration during embryonic development, organogenesis and …
proliferation, survival and migration during embryonic development, organogenesis and …
bFGF protects against oxygen glucose deprivation/reoxygenation-induced endothelial monolayer permeability via S1PR1-dependent mechanisms
Blood-brain barrier (BBB) disruption is a common pathological feature of many neurological
disorders including stroke and brain trauma, therefore is an important therapeutic target for …
disorders including stroke and brain trauma, therefore is an important therapeutic target for …
Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor
E Frullanti, C Berking, N Harbeck… - European Journal of …, 2011 - journals.lww.com
Fibroblast growth factor receptor 4 (FGFR4) contains a Gly388Arg functional polymorphism
(rs351855) that has shown contrasting results in association studies. In this study, we …
(rs351855) that has shown contrasting results in association studies. In this study, we …
The FGFR4-388arg variant promotes lung cancer progression by N-cadherin induction
Á Quintanal-Villalonga, L Ojeda-Márquez, Á Marrugal… - Scientific reports, 2018 - nature.com
The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer,
including lung cancer. The mechanism underlying this association has not been addressed …
including lung cancer. The mechanism underlying this association has not been addressed …