Saffron bioactives crocin, crocetin and safranal: Effect on oxidative stress and mechanisms of action

D Cerdá-Bernad, E Valero-Cases… - Critical reviews in …, 2022 - Taylor & Francis
Saffron (Crocus sativus L.) is used as a spice for its organoleptic characteristics related to its
coloring and flavoring properties, and it has been also used in traditional medicine to treat …

[HTML][HTML] Neuroprotective potency of saffron against neuropsychiatric diseases, neurodegenerative diseases, and other brain disorders: from bench to bedside

Y Bian, C Zhao, SMY Lee - Frontiers in Pharmacology, 2020 - frontiersin.org
The increasing morbidity rates of brain disorders and conditions such as anxiety,
depression, Alzheimer's disease, and Parkinson's disease have become a severe problem …

Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis

W Marx, M Lane, T Rocks, A Ruusunen… - Nutrition …, 2019 - academic.oup.com
Abstract Context Saffron (Crocus sativus L.) has gained interest as a potential treatment in
psychiatry. Objective This systematic review and meta-analysis sought to investigate the …

[HTML][HTML] Saffron and its active ingredients against human disorders: A literature review on existing clinical evidence

SF Omidkhoda, H Hosseinzadeh - Iranian Journal of Basic Medical …, 2022 - ncbi.nlm.nih.gov
Saffron, the stigmas of Crocus sativus L., has been mentioned extensively in the traditional
reference texts as a herbal medicine. Many clinical trials have been conducted on this …

The efficacy of saffron in the treatment of mild to moderate depression: a meta-analysis

B Tóth, P Hegyi, T Lantos, Z Szakacs, B Kerémi… - Planta …, 2019 - thieme-connect.com
Herbal products, especially Hypericum perforatum extracts, have been widely used as first-
line treatments for mild to moderate depression. Recently, several randomized, controlled …

Safety and efficacy of saffron (Crocus sativus L.) for treating mild to moderate depression: a systematic review and meta-analysis

L Dai, L Chen, W Wang - The Journal of nervous and mental …, 2020 - journals.lww.com
Background Herbal remedies are becoming increasingly popular for the treatment of
depression. Recently, accumulating evidences reveal a positive effect of saffron (Crocus …

[HTML][HTML] Toxicity of saffron extracts on cancer and normal cells: A review article

M Shakeri, AH Tayer, H Shakeri… - Asian Pacific journal …, 2020 - ncbi.nlm.nih.gov
Methods: This review aims to provide an overview of in-vitro and in-vivo evaluation molecule
mechanism for anti-tumor activity, cancer preventing and protective effects of saffron extract …

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

R Matraszek-Gawron, M Chwil, K Terlecki… - Pharmaceuticals, 2022 - mdpi.com
Psychotropic effect of Crocus sativus L.(family Iridaceae) biologically active chemical
compounds are quite well documented and they can therefore be used in addition to the …

Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication for the treatment of persistent depressive symptoms in adults: A …

AL Lopresti, SJ Smith, SD Hood… - Journal of …, 2019 - journals.sagepub.com
Background: As a stand-alone intervention, saffron has efficacy for the treatment of mild-to-
moderate depression. However, research as an adjunct agent is limited. Aims: The effects of …

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

A Khan, NA Muhamad, H Ismail, A Nasir, AAK Khalil… - Plants, 2020 - mdpi.com
Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to
cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic …