Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Cullin proteins are molecular scaffolds that have crucial roles in the post-translational
modification of cellular proteins involving ubiquitin. The mammalian cullin protein family …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …

Recent genetic studies have documented a pivotal growth-regulatory role played by the
Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting …

Background Tumour metastasis to the brain is a common and deadly development in certain
cancers; 18–30% of breast tumours metastasise to the brain. The contribution that gene …

The proper formation and morphogenesis of dendrites is fundamental to the establishment
of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo …

3-M syndrome, a primordial growth disorder, is associated with mutations in CUL7 and
OBSL1. Exome sequencing now identifies mutations in CCDC8 as a cause of 3-M …

Background Hereditary short stature syndromes are clinically and genetically
heterogeneous disorders and the cause have not been fully identified. Yakuts are a …

Biomolecular condensates have been proposed to mediate cellular signaling transduction.
However, the mechanism and functional consequences of signal condensates are not well …

Abstract The SCF (SKP1 (S-phase-kinase-associated protein 1), Cullin-1, F-box protein) E3
ubiquitin ligases, the founding member of Cullin-RING ligases (CRLs), are the largest family …