Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe
Ancient genomics can directly detect human genetic adaptation to environmental cues.
However, it remains unclear how pathogens have exerted selective pressures on human …
However, it remains unclear how pathogens have exerted selective pressures on human …
High-coverage genome of the Tyrolean Iceman reveals unusually high Anatolian farmer ancestry
Summary The Tyrolean Iceman is known as one of the oldest human glacier mummies,
directly dated to 3350–3120 calibrated BCE. A previously published low-coverage genome …
directly dated to 3350–3120 calibrated BCE. A previously published low-coverage genome …
Population differentiation of polygenic score predictions under stabilizing selection
Given the many small-effect loci uncovered by genome-wide association studies (GWAS),
polygenic scores have become central to genomic medicine, and have found application in …
polygenic scores have become central to genomic medicine, and have found application in …
Medieval social landscape through the genetic history of Cambridgeshire before and after the Black Death
The extent of the devastation of the Black Death pandemic (1346-53) on European
populations is known from documentary sources and its bacterial source illuminated by …
populations is known from documentary sources and its bacterial source illuminated by …
[HTML][HTML] Testing for differences in polygenic scores in the presence of confounding
J Blanc, JJ Berg - BioRxiv, 2023 - ncbi.nlm.nih.gov
Polygenic scores have become an important tool in human genetics, enabling the prediction
of individuals' phenotypes from their genotypes. Understanding how the pattern of …
of individuals' phenotypes from their genotypes. Understanding how the pattern of …
The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection
Stabilizing selection on a polygenic trait reduces the trait's genetic variance by (i) generating
correlations (linkage disequilibria) between opposite-effect alleles throughout the genome …
correlations (linkage disequilibria) between opposite-effect alleles throughout the genome …
[图书][B] Selection and Introgression in Humans and Other Animals
S Yair - 2022 - search.proquest.com
Many longstanding questions in evolution concern the major forces that shape genetic
variation in natural populations: natural selection, genetic drift, mutation, gene flow, and …
variation in natural populations: natural selection, genetic drift, mutation, gene flow, and …