Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene
mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid …

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine
kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug …

Compartmentalization of signals generated by receptor tyrosine kinase (RTK) endocytosis
has emerged as a major determinant of various cell functions. Here, using tumour …

Abstract Pim kinases are Ser/Thr kinases with multiple substrates that affect survival
pathways. These proteins are overexpressed in acute myeloid leukemia (AML) blasts and …

Congenital neutropenias (CNs) are rare heterogeneous genetic disorders, with about 25%
of patients without known genetic defects. Using whole-exome sequencing, we identified a …

The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …

Simple Summary AML is a genetically heterogeneous disease with a median age of
diagnosis between 60 and 70 years. Thus, many AML patients are not eligible for intensive …

The fms-related tyrosine kinase 3 (FLT3) receptor has been extensively studied over the
past two decades with regard to oncogenic alterations that do not only serve as prognostic …

Internal tandem duplication within FLT3 (FLT3-ITD) is one of the most frequent mutations in
acute myeloid leukemia (AML) and correlates with a poor prognosis. Whereas the FLT3 …

A large number of alterations in genes encoding receptor tyrosine kinase (RTK), namely
FLT3, c-KIT, platelet-derived growth factor (PDGF) receptors, fibroblast growth factor (FGF) …