Lymphatic vessels have critical roles in both health and disease and their study is a rapidly
evolving area of vascular biology. The consensus on how the first lymphatic vessels arise in …

Endothelial cells display an extraordinary plasticity both during development and throughout
adult life. During early development, endothelial cells assume arterial, venous, or lymphatic …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate …

Quantifying the number of progenitor cells that found an organ, tissue or cell population is of
fundamental importance for understanding the development and homeostasis of a …

The lymphatic system plays important roles in physiological and pathological conditions.
During cancer progression in particular, lymphangiogenesis can exert both positive and …

The cell lineages across developmental stages remain to be elucidated. Here, we
developed single-cell split barcoding (SISBAR) that allows clonal tracking of single-cell …

Stem cells or their closely related committed progenitor cells are the likely founder cells of
most neoplasms. In the continually renewing and hierarchically organized epithelia of the …

The current gold-standard for genetic lineage tracing in transgenic mice is based on cell-
type specific expression of Cre recombinase. As an alternative, we developed a cell-type …

Quantifying the number of progenitor cells that founder an organ, tissue or cell population is
of fundamental value for understanding the development and homeostasis of a multicellular …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
Yet, the functional relevance of deriving a specific cell type from ontologically distinct …