Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response
to viral infections. In response to viral stimuli, cells produce and release interferons, which …

African swine fever is a devastating disease of swine caused by African swine fever virus
(ASFV). The pathogenesis of the disease remains largely unknown, leaving the spread of …

The interferon regulatory factor (IRF) family of transcription factors play a vital role in the
human innate antiviral immune responses with production of interferons (IFNs) as a hallmark …

Innate immunity is not only the first line of host defense against microbial infections but is
also crucial for the host responses against a variety of noxious stimuli. Z-DNA binding …

The cGAS/STING signaling pathway is a crucial component of the innate immune system,
playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and …

The innate immune system is the first line of the host's defense, and studying the
mechanisms of the negative regulation of interferon (IFN) signaling is important for …

Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from
generating energy, regulating the metabolic processes, cell death to inflammation. The most …

Influenza virus possesses an RNA genome of single-stranded, negative-sensed, and
segmented configuration. Influenza virus causes an acute respiratory disease, commonly …

Summary Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate
immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …