GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

Diazepam (Valium) is among the most successful drugs from the onset of the
psychopharmacological revolution that began during the 1950s. Efficacious in treating a …

GABAA receptors are ligand-operated chloride channels assembled from five subunits in a
heteropentameric manner. Using immunocytochemistry, we investigated the distribution of …

This article does not aim to review in detail the properties of-aminobutyric acidA (GABAA) b
receptors, because recent accounts of that topic are available. In this same journal, a review …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Functional and molecular analysis of glial voltage-and ligand-gated ion channels underwent
tremendous boost over the last 15 years. The traditional image of the glial cell as a passive …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

There has been a resurgence of interest in synthetic and plant‐derived flavonoids as
modulators of γ‐amino butyric acid‐A (GABAA) receptor function influencing inhibition …