Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Progressive cerebral deposition of the amyloid β-protein (Aβ) in brain regions serving
memory and cognition is an invariant and defining feature of Alzheimer disease. A highly …

Introduction• Protein aggregation‐'Toxic oligomer'hypothesis‐Protein (mis) folding‐
Proteostasis and molecular chaperones‐Protein misfolding and endoplasmic reticulum …

The toxicity of amyloid‐forming proteins is correlated with their interactions with cell
membranes. Binding events between amyloidogenic proteins and membranes result in …

Neurodegenerative diseases are featured by progressive dysfunction and death of cells in
selected areas in the nervous system, determining clinical presentation. Neuronal loss is …

The presence of surfaces influences the fibril formation kinetics of peptides and proteins. We
present a systematic study of the aggregation kinetics of amyloidogenic peptides caused by …

Amyloid β proteins and oxidative stress are believed to have central roles in the
development of Alzheimer's disease. Lipid membranes are among the most vulnerable …

A crucial stage in the origin of life was the emergence of the first molecular entity that was
able to replicate, transmit information, and evolve on the early Earth. The amyloid world …

The electrical charge of biological membranes and thus the resulting alignment of water
molecules in response to this charge are important factors affecting membrane rigidity …

Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
dementia and memory loss for which no cure or effective prevention is currently available …