The role of flavonoids in autoimmune diseases: Therapeutic updates

KRR Rengasamy, H Khan, S Gowrishankar… - Pharmacology & …, 2019 - Elsevier
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …

On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective

Z Nouri, S Fakhri, FF El-Senduny, N Sanadgol… - Biomolecules, 2019 - mdpi.com
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …

Review of the applications of biomedical compositions containing hydroxyapatite and collagen modified by bioactive components

A Sobczak-Kupiec, A Drabczyk, W Florkiewicz, M Głąb… - Materials, 2021 - mdpi.com
Regenerative medicine is becoming a rapidly evolving technique in today's biomedical
progress scenario. Scientists around the world suggest the use of naturally synthesized …

Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models

GR Gandhi, MTSL Neta, RG Sathiyabama… - Phytomedicine, 2018 - Elsevier
Background Flavonoids are naturally occurring compounds, extensively distributed in plants.
T helper (Th) 1 and Th2 cytokines balance plays an essential role in the reaction of …

Naringin in combination with isothiocyanates as liposomal formulations potentiates the anti-inflammatory activity in different acute and chronic animal models of …

S Mohanty, AK Sahoo, VB Konkimalla, A Pal, SC Si - ACS omega, 2020 - ACS Publications
Combination of drugs is extensively used to treat chronic inflammatory disease. Naringin
(NAR), sulforaphane (SFN), and phenethyl isothiocyanate (PEITC) are nutraceuticals with …

Naringenin: its chemistry and roles in neuroprotection

AV Atoki, PM Aja, TS Shinkafi, EN Ondari… - Nutritional …, 2024 - Taylor & Francis
According to epidemiological research, as the population ages, neurological illnesses are
becoming a bigger issue. Despite improvements in the treatment of these diseases, there …

Dexamethasone attenuates LPS-induced acute lung injury through inhibition of NF-κB, COX-2, and pro-inflammatory mediators

NO Al-Harbi, F Imam, MM Al-Harbi… - Immunological …, 2016 - Taylor & Francis
Dexamethasone (DEX) is a synthetic glucocorticoid with potent anti-inflammatory effects that
is widely used to treat inflammatory diseases. The aim of the present study was to …

Naringin as sustained delivery nanoparticles ameliorates the anti-inflammatory activity in a Freund's complete adjuvant-induced arthritis model

S Mohanty, VB Konkimalla, A Pal, T Sharma, SC Si - ACS omega, 2021 - ACS Publications
Naringin (NAR), a naturally occurring essential flavonoid, present in grapefruit and Chinese
herbal medicines, creates great interest in researchers due to its diverse biological and …

Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint …

SF Ahmad, MA Ansari, KMA Zoheir, SA Bakheet… - Immunobiology, 2015 - Elsevier
Abstract Histamine 4 receptor (H4R) is a novel target for the pharmacological modulation of
histamine-mediated immune signals during inflammatory diseases. The purpose of this …

Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-κB activation against LPS-induced acute lung injury in mice

F Imam, NO Al-Harbi, MM Al-Harbi, MA Ansari… - Pharmacological …, 2015 - Elsevier
Diosmin, a natural flavonoid glycoside present abundantly in the pericarp of various citrus
fruits. Because of its anti-inflammatory and antioxidant properties, it can be used in many …