Effects of cyclodextrins on the chemical stability of drugs

A Popielec, T Loftsson - International Journal of Pharmaceutics, 2017 - Elsevier
Cyclodextrins (CDs) are enabling pharmaceutical excipients that can enhance both
solubility and stability of wide variety of drugs in aqueous solutions through formation of …

5‑Fluorouracil loaded chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel as a potential anticancer drug delivery system

MS Amini-Fazl, R Mohammadi, K Kheiri - International journal of biological …, 2019 - Elsevier
In most cancer treatments, chemotherapy is currently necessary; hence, more attention was
devoted to developing new methods for designing drug delivery systems (DDS) with …

Anti-HER2/neu peptide-conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells

Q Mu, FM Kievit, RJ Kant, G Lin, M Jeon, M Zhang - Nanoscale, 2015 - pubs.rsc.org
Nanoparticles (NPs) for targeted therapy are required to have appropriate size, stability,
drug loading and release profiles, and efficient targeting ligands. However, many of the …

Nano-engineered mesenchymal stem cells as targeted therapeutic carriers

T Sadhukha, TD O'Brien, S Prabha - Journal of controlled Release, 2014 - Elsevier
Poor availability in deep-seated solid tumors is a significant challenge that limits the
effectiveness of currently used anticancer drugs. Approaches that can specifically enhance …

Alginate hydrogels functionalized with β‐cyclodextrin as a local paclitaxel delivery system

LA Omtvedt, KA Kristiansen, WI Strand… - … Research Part A, 2021 - Wiley Online Library
Modification of drug delivery materials with beta‐cyclodextrins (β‐CyD) is known to increase
solubility of poorly water‐soluble drugs, protect drugs from degradation and sustain release …

Development and characterization of lung surfactant-coated polymer nanoparticles for pulmonary drug delivery

A Gonsalves, P Sorkhdini, J Bazinet, M Ghumman… - Biomaterials …, 2023 - Elsevier
Lung cancer is often diagnosed at an advanced stage where tumors are usually inoperable
and first-line therapies are inefficient and have off-targeted adverse effects, resulting in poor …

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced …

K De Clercq, F Xie, O De Wever, B Descamps… - Scientific Reports, 2019 - nature.com
Patients with advanced ovarian cancer develop recurrence despite initial treatment
response to standard treatment of surgery and intravenous/intraperitoneal (IP) …

Investigation of mathematical models based on diffusion control release for Paclitaxel from in-situ forming PLGA microspheres containing HSA microparticles

MS Amini-Fazl, H Mobedi - Materials Technology, 2020 - Taylor & Francis
Paclitaxel-loaded poly (lactic acid-co-glycolic acid)(PLGA) microspheres containing different
portions of human serum albumin microparticles (mHSA) were prepared via an in situ …

Impact of Nebulization on the Physicochemical Properties of Polymer–Lipid Hybrid Nanoparticles for Pulmonary Drug Delivery

A Gonsalves, JU Menon - International Journal of Molecular Sciences, 2024 - mdpi.com
Nanoparticles (NPs) have shown significant potential for pulmonary administration of
therapeutics for the treatment of chronic lung diseases in a localized and sustained manner …

Biodegradation study of PLGA as an injectable in situ depot-forming implant for controlled release of paclitaxel

MS Amini-Fazl - Polymer Bulletin, 2021 - Springer
In this study, poly (d, l-lactide-co-glycolide), PLGA, was developed as an in situ forming
implants (ISFIs) to improve the therapeutic efficiency and to devoid the adverse effects of the …