Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …

Identification of B‐cell epitopes is a fundamental step for development of epitope‐based
vaccines, therapeutic antibodies, and diagnostic tools. Epitope‐based antibodies are …

B‐cell epitope prediction tools are of great medical and commercial interest due to their
practical applications in vaccine development and disease diagnostics. The introduction of …

A key challenge of modern biology is to uncover the functional role of the protein entities that
compose cellular proteomes. To this end, the availability of reliable three-dimensional …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Background Reliable prediction of antibody, or B-cell, epitopes remains challenging yet
highly desirable for the design of vaccines and immunodiagnostics. A correlation between …

B‐cell epitopes play a vital role in the development of peptide vaccines, in diagnosis of
diseases, and also for allergy research. Experimental methods used for characterizing …

Discovery of discontinuous B‐cell epitopes is a major challenge in vaccine design. Previous
epitope prediction methods have mostly been based on protein sequences and are not very …

Monoclonal antibodies are playing an increasing role in both human and animal health.
Different strategies of protein and chemical engineering, including humanization techniques …

Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …