Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of
chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in …

A variety of neurotrophic factors have been used in attempts to improve morphological and
behavioural outcomes after experimental spinal cord injury (SCI). Here we review many of …

Embryonic neurons, peripheral neurons, and CNS neurons in zebrafish respond to axon
injury by initiating pro-regenerative transcriptional programs that enable axons to extend …

The application of neurotrophic factors as a therapy to improve morphological and
behavioral outcomes after experimental spinal cord injury (SCI) has been the focus of many …

Spinal cord injury often results in devastating consequences for those afflicted, with very few
therapeutic options. A central element of spinal cord injuries is astrogliosis, which forms a …

Retrogradely-transported neurotrophin signaling plays an important role in regulating neural
circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to …

The aim of this prospective randomized double-blind clinical study is to examine the benefits
of using olfactory ensheathing cells (OECs) combined with or without Schwann cells (SCs) …

Axonal growth inhibitors are released during traumatic injuries to the adult mammalian
central nervous system, including after spinal cord injury. These molecules accumulate at …

To restore function after injury to the CNS, axons must be stimulated to extend into
denervated territory and, critically, must form functional synapses with appropriate targets …

NG2 is a structurally unique transmembrane chondroitin sulfate proteoglycan (CSPG). Its
role in damaged spinal cord is dual. NG2 is considered one of key inhibitory factors …