Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Collective invasion drives the spread of multicellular cancer groups, into the normal tissue
surrounding several epithelial tumors. Collective invasion recapitulates various aspects of …

Purpose: Carcinomas originate from epithelial tissues, which have apical (luminal) and
basal orientations. The degree of luminal versus basal differentiation in cancer has been …

Lineage plasticity is important for the development of basal-like breast cancer (BLBC), an
aggressive cancer subtype. While BLBC is likely to originate from luminal progenitor cells, it …

Breast cancer, the most frequent cancer in women, is generally classified into several
distinct histological and molecular subtypes. However, single-cell technologies have …

Nanoparticles made from membrane of mesenchymal stem cells (MSCs) showed active
targeting capacities to prostate and lung cancers, but further studies are hindered by limited …

Dense and aligned Collagen I fibers are associated with collective cancer invasion led by
protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells …

Osteosarcoma is the most common malignant bone tumor, and although there has been
significant progress in its management, metastases often herald incurable disease. Here we …

The majority of women with ovarian cancer are diagnosed with metastatic disease, therefore
elucidating molecular events that contribute to successful metastatic dissemination may …

Our previous study showed that adhesion molecule with immunoglobulin like domain 2
(AMIGO2) is a pivotal driver gene of liver metastasis via regulating tumor cell adhesion to …