Insights into the evolution of hemoglobins and their genes are an abundant source of ideas
regarding hemoglobin function and regulation of globin gene expression. This article …

Globins are haem‐proteins that bind O2 and thus play an important role in the animal's
respiration and oxidative energy production. However, globins may also have other …

Cancer progression is an intricate biological process profiled by not only unscheduled
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …

In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo
regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin …

Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial
cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are …

Mammalian macrophages can adopt polarization states that, depending on the exact stimuli
present in their extracellular environment, can lead to very different functions. Although …

Cell-derived extracellular vesicles (EVs) are involved in the pathogenesis of rheumatoid
arthritis (RA), playing important roles in antigen presentation, inflammation, angiogenesis …

Members of the hemoglobin superfamily efficiently catalyze nitric‐oxide dioxygenation, and
when paired with native electron donors, function as NO dioxygenases (NODs). Indeed, the …

Cytoglobin is a heme-containing protein ubiquitous in mammalian tissues. Unlike the
evolutionarily related proteins hemoglobin and myoglobin, cytoglobin shows a six …