Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

The synthesis and biological evaluation of new potent hydroxamate-based HDAC inhibitors
with a novel alkoxyamide connecting unit linker region are described. Biological evaluation …

HDAC 4, 5, 7 and 9 constitute the class II a histone deacetylases (HDAC s) within the large
family of protein deacetylases. Class II a HDAC s have unique features that distinguish them …

Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful
metabolic by-products when discovered in the mid-19th century in the urine of patients with …

Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, which is associated with
learning and memory impairment in the elderly. Recent studies have found that treating AD …