The Latin word" facultas" literally means" opportunity." Facultative heterochromatin (fHC)
then designates genomic regions in the nucleus of a eukaryotic cell that have the …

The lysine-rich H1 histone family in mammals includes eleven different subtypes, and thus it
is the most divergent class of histone proteins. The central globular H1 domain …

Cell differentiation in embryogenesis involves extensive changes in gene expression
structural reorganization within the nucleus, including chromatin condensation and …

Background Linker histone H1 is a structural component of chromatin. It exists as a family of
related proteins known as variants and/or subtypes. H1. 1, H1. 2, H1. 3, H1. 4 and H1. 5 are …

There are seven linker histone variants in human somatic cells (H1. 0 to H1. 5 and H1X),
and their prevalence varies as a function of cell type and differentiation stage, suggesting …

H1 linker histones are key chromatin architectural proteins facilitating the formation of higher
order chromatin structures. The H1 family constitutes the most heterogeneous group of …

The linker histone H1 has a fundamental role in DNA compaction. Although models for H1
binding generally involve the H1 C‐terminal tail and sites S1 and S2 within the H1 globular …

Terminal erythroid differentiation in vertebrates is characterized by progressive
heterochromatin formation and chromatin condensation and, in mammals, culminates in …

Red blood cells, or erythrocytes, make up approximately a quarter of all cells in the human
body with over 2 billion new erythrocytes made each day in a healthy adult human. This …

An immortalized neural cell line derived from the human ventral mesencephalon, called
ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin …