Immune escape and immunotherapy of acute myeloid leukemia

L Vago, I Gojo - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
In spite of the recent approval of new promising targeted therapies, the clinical outcome of
patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for …

Cytokines and costimulation in acute graft-versus-host disease

GR Hill, M Koyama - Blood, The Journal of the American …, 2020 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning

SR McCurdy, V Radojcic, HL Tsai… - Blood, The Journal …, 2022 - ashpublications.org
The key immunologic signatures associated with clinical outcomes after posttransplant
cyclophosphamide (PTCy)-based HLA-haploidentical (haplo) and HLA-matched bone …

Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma

RW Merryman, L Castagna, L Giordano, VT Ho… - Leukemia, 2021 - nature.com
Anti-PD-1 monoclonal antibodies yield high response rates in patients with
relapsed/refractory classic Hodgkin lymphoma (cHL), but most patients will eventually …

Immune checkpoint inhibition in acute myeloid leukemia and myelodysplastic syndromes

Y Abaza, AM Zeidan - Cells, 2022 - mdpi.com
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many solid tumors,
with limited progress made in the area of myeloid malignancies. The low mutational burden …

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

BR Blazar, GR Hill, WJ Murphy - Nature Reviews Clinical Oncology, 2020 - nature.com
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was the first successful
therapy for patients with haematological malignancies, predominantly owing to graft-versus …

Posttransplantation cyclophosphamide improves transplantation outcomes in patients with AML/MDS who are treated with checkpoint inhibitors

B Oran, G Garcia‐Manero, RM Saliba, M Alfayez… - Cancer, 2020 - Wiley Online Library
Background There have been concerns regarding increased peritransplantation
complications, especially severe acute graft‐versus‐host disease (aGVHD), in patients with …

Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis

P Berning, N Schmitz, M Ngoya, H Finel, A Boumendil… - Leukemia, 2023 - nature.com
Natural killer/T-cell lymphomas (NKTCL) represent rare and aggressive lymphoid
malignancies. Patients (pts) with relapsed/refractory disease after Asparaginase (ASPA) …

Relapse after allogeneic transplantation with post-transplant cyclophosphamide: Shattering myths and evolving insight

SR McCurdy, L Luznik - Blood Reviews, 2023 - Elsevier
Early studies in allogeneic blood or marrow transplantation (alloBMT) demonstrated that
HLA-mismatching was protective again relapse. However, benefits in relapse reduction …

[HTML][HTML] Non-myeloablative allogeneic transplantation with post-transplant cyclophosphamide after immune checkpoint inhibition for classic Hodgkin lymphoma: a …

S Paul, M Zahurak, L Luznik, RF Ambinder… - Biology of Blood and …, 2020 - Elsevier
Immune checkpoint inhibitors (ICIs) are approved in relapsed classic Hodgkin lymphoma
(cHL). The safety and effectiveness of allogeneic blood or marrow transplantation (alloBMT) …