The host inflammatory response against infections is characterized by the release of pro-
inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Abstract IL-17-producing CD4+ T helper cells (TH17) have been extensively investigated in
mouse models of autoimmunity. However, the requirements for differentiation and the …

Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

Chronic inflammation is the basis of various chronic illnesses including cancer and vascular
diseases. However, much has yet to be learned how inflammation becomes chronic …

Abstract T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the
effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

Mesenchymal stem cells (MSCs) are being increasingly investigated as a therapeutic
alternative, not only for their possible regenerative potential but also for their …

Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication
while preventing an over-exuberant inflammatory response. Interferon (IFN) γ is crucial for …

RORγt is a lineage-specifying transcription factor that is expressed by immune cells that are
enriched in the gastrointestinal tract and promote immunity, inflammation and tissue …