Intracranial self-stimulation to evaluate abuse potential of drugs

SS Negus, LL Miller - Pharmacological reviews, 2014 - ASPET
Intracranial self-stimulation (ICSS) is a behavioral procedure in which operant responding is
maintained by pulses of electrical brain stimulation. In research to study abuse-related drug …

Dopaminergic dysregulation in syndromic autism spectrum disorders: insights from genetic mouse models

P Kosillo, HS Bateup - Frontiers in Neural Circuits, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by altered social
interaction and communication, and repetitive, restricted, inflexible behaviors. Approximately …

Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism

OY Chao, SS Pathak, H Zhang, N Dunaway, JS Li… - Molecular brain, 2020 - Springer
The dopamine (DA) system has a profound impact on reward-motivated behavior and is
critically involved in neurodevelopmental disorders, such as autism spectrum disorder …

FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability

A D'Elia, S Schiavi, A Manduca, A Rava, V Buzzelli… - Scientific Reports, 2022 - nature.com
Abstract Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder
emerging in early life characterized by impairments in social interaction, poor verbal and …

RNA‐binding proteins, neural development and the addictions

CD Bryant, N Yazdani - Genes, Brain and Behavior, 2016 - Wiley Online Library
Transcriptional and post‐transcriptional regulation of gene expression defines the
neurobiological mechanisms that bridge genetic and environmental risk factors with …

Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse

EM Sørensen, F Bertelsen, P Weikop… - Behavioural …, 2015 - journals.lww.com
The aims of this study were to investigate behaviour relevant to human autism spectrum
disorder (ASD) and the fragile X syndrome in adolescent Fmr1 knockout (KO) mice and to …

Influence of gestational chlorpyrifos exposure on ASD-like behaviors in an fmr1-KO rat model

C Perez-Fernandez, M Matamala Montoya… - Molecular …, 2022 - Springer
Based on previous reports, exposure to pesticides could be linked to the prevalence
increase of autism spectrum disorders (ASD). Gestational exposure to chlorpyrifos (CPF) …

Protein translation in the nucleus accumbens is dysregulated during cocaine withdrawal and required for expression of incubation of cocaine craving

CT Werner, MT Stefanik, M Milovanovic… - Journal of …, 2018 - Soc Neuroscience
Exposure to drug-associated cues can induce drug craving and relapse in abstinent addicts.
Cue-induced craving that progressively intensifies (“incubates”) during withdrawal from …

Dopaminergic dysfunction in neurodevelopmental disorders: recent advances and synergistic technologies to aid basic research

JE Robinson, V Gradinaru - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Dopaminergic dysfunction is common in many neurodevelopmental
disorders.•New circuit mapping tools have refined our knowledge of these circuits at …

Parallel learning and cognitive flexibility impairments between Fmr1 knockout mice and individuals with fragile X syndrome

LM Schmitt, AL Arzuaga, A Dapore… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Fragile X Syndrome (FXS) is a monogenic condition that leads to intellectual
disability along with behavioral and learning difficulties. Among behavioral and learning …