Dystonia is a clinically and genetically highly heterogeneous neurological disorder
characterized by abnormal movements and postures caused by involuntary sustained or …

This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …

DYT-TOR1A dystonia is a neurological disorder characterized by involuntary muscle
contractions and abnormal movements. It is a severe genetic form of dystonia caused by …

The discovery of biological pathways shared between different monogenic dystonias is an
important conceptual advance in the understanding of the underlying mechanisms, with a …

Dystonia, the third most common movement disorder, refers to a heterogeneous group of
neurological diseases characterized by involuntary, sustained or intermittent muscle …

Huntington's Disease (HD) is a devastating disorder characterized by a triad of motor,
psychiatric and cognitive manifestations. Psychiatric and emotional symptoms appear at …

Brain lesions exclusive to dystonia, or specific forms of it, such as isolated dystonia, have
been rarely described. While the identification of distinctive intra-or extraneuronal …

Murine models are fundamental in the study of clinical conditions and the development of
new drugs and treatments. Transgenic technology has started to offer advantages in …

Parkinson disease is a complex and multifactorial disorder, but how its biological and
clinical complexity emerge from molecular to macroscopic brain interactions remains poorly …

DYT1 dystonia is associated with decreased striatal dopamine release. In this study, we
examined the possibility that ultrastructural changes of nigrostriatal dopamine terminals …