An overview of PROTACs: a promising drug discovery paradigm
Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic
paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target …
paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target …
HIV expression in infected T cell clones
JW Rausch, S Parvez, S Pathak, AA Capoferri… - Viruses, 2024 - mdpi.com
The principal barrier to an HIV-1 cure is the persistence of infected cells harboring
replication-competent proviruses despite antiretroviral therapy (ART). HIV-1 transcriptional …
replication-competent proviruses despite antiretroviral therapy (ART). HIV-1 transcriptional …
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence
Understanding how HIV-1-infected cells proliferate and persist is key to HIV-1 eradication,
but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations …
but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations …
Improving prediction performance of general protein language model by domain-adaptive pretraining on DNA-binding protein
DNA-protein interactions exert the fundamental structure of many pivotal biological
processes, such as DNA replication, transcription, and gene regulation. However, accurate …
processes, such as DNA replication, transcription, and gene regulation. However, accurate …
Discovery and preclinical pharmacology of NX-2127, an orally bioavailable degrader of Bruton's tyrosine kinase with immunomodulatory activity for the treatment of …
DW Robbins, MA Noviski, YS Tan… - Journal of Medicinal …, 2024 - ACS Publications
Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, is an essential
effector of B-cell receptor (BCR) signaling. Chronic activation of BTK-mediated BCR …
effector of B-cell receptor (BCR) signaling. Chronic activation of BTK-mediated BCR …
T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients
HS Kuehn, J Chang, M Yamashita… - Journal of Experimental …, 2021 - rupress.org
AIOLOS/IKZF3 is a member of the IKAROS family of transcription factors. IKAROS/IKZF1
mutations have been previously associated with different forms of primary …
mutations have been previously associated with different forms of primary …
Transcriptional reprogramming by mutated IRF4 in lymphoma
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …
In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities
E Ten Hacken, T Sewastianik, S Yin, GB Hoffmann… - Blood cancer …, 2023 - AACR
Transformation to aggressive disease histologies generates formidable clinical challenges
across cancers, but biological insights remain few. We modeled the genetic heterogeneity of …
across cancers, but biological insights remain few. We modeled the genetic heterogeneity of …
Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals
Gene regulatory elements drive complex biological phenomena and their mutations are
associated with common human diseases. The impacts of human regulatory variants are …
associated with common human diseases. The impacts of human regulatory variants are …
Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression
M Quijada-Álamo, M Hernández-Sánchez… - Blood Cancer …, 2021 - nature.com
BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …
harboring del (11q). In addition, truncating mutations in the remaining allele of this gene can …