Cell-derived nanovesicle-mediated drug delivery to the brain: principles and strategies for vesicle engineering

Y Liang, Z Iqbal, J Lu, J Wang, H Zhang, X Chen… - Molecular Therapy, 2023 - cell.com
Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …

Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy

J Chen, J Pan, S Liu, Y Zhang, S Sha, H Guo… - Advanced …, 2023 - Wiley Online Library
Existing solid‐nanoparticle‐based drug delivery systems remain a great challenge for
glioblastoma chemotherapy due to their poor capacities in crossing the blood–brain …

Brain‐targeted HFn‐Cu‐rego nanoplatform for site‐specific delivery and manipulation of autophagy and cuproptosis in glioblastoma

W Jia, H Tian, J Jiang, L Zhou, L Li, M Luo, N Ding… - Small, 2023 - Wiley Online Library
Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …

[HTML][HTML] Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases

C Wang, M Xu, Q Fan, C Li, X Zhou - Asian journal of pharmaceutical …, 2023 - Elsevier
In the inflammatory microenvironment, there are numerous exosomes secreted by immune
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …

[HTML][HTML] Small extracellular vesicles: non-negligible vesicles in tumor progression, diagnosis, and therapy

X Zhou, Y Jia, C Mao, S Liu - Cancer Letters, 2024 - Elsevier
Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles
(< 200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Engineering therapeutical extracellular vesicles for clinical translation

Y Ma, S Dong, AJ Grippin, L Teng, AS Lee… - Trends in …, 2024 - cell.com
Cell-based therapies are revolutionizing medicine by replacing or modifying dysfunctional
cells with healthy cells or engineered derivatives, offering disease reversal and cure. One …

Nanotherapeutics overcoming the blood-brain barrier for glioblastoma treatment

L Tang, Y Feng, S Gao, Q Mu, C Liu - Frontiers in Pharmacology, 2021 - frontiersin.org
Glioblastoma (GBM) is the most common malignant primary brain tumor with a poor
prognosis. The current standard treatment regimen represented by temozolomide …

Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

M Shao, D Lopes, J Lopes, S Yousefiasl… - Matter, 2023 - cell.com
Bio-mimicking principles have recently been proposed for the surface functionalization of
nanoparticles (NPs). Such a strategy is based on camouflaging the NP surface with …