The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic
causes make a significant contribution to ischemic stroke genesis, especially in early-onset …

Marfan syndrome (MFS) is a rare inherited autosomic disorder, which encompasses a
variety of systemic manifestations caused by mutations in the Fibrillin-1 encoding gene …

The exact molecular pathways underlying the multifactorial natural history of intracranial
aneurysms (IAs) are still largely unknown, to the point that their understanding represents an …

In modern society, subarachnoid hemorrhage, mostly caused by intracranial aneurysm
rupture, is accompanied by high disability and mortality rate, which has become a major …

OBJECTIVE Loeys-Dietz syndrome (LDS) is a heritable aortopathy associated with
craniofacial abnormalities and dilatation and dissection of the aorta and its branches, as well …

Although new consensus guidelines have emerged to facilitate the diagnosis of those with
vEDS, there remain limitations in terms of interventions and medical therapy that can be …

Background Ehlers-Danlos type IV or vascular Ehlers-Danlos syndrome (vEDS) is a rare
inherited disorder characterized by profound vascular fragility resulting from defective …

Aortic aneurysms, including thoracic aortic aneurysms and abdominal aortic aneurysms, are
life-threatening macrovascular diseases with high mortality. The already known key …

Introduction Stroke is one of the main causes of death and disability worldwide.
Nevertheless, despite the global burden of this disease, our understanding is limited and …

Aneurysmal lesions are commonly seen in Ehlers‐Danlos Syndrome (EDS). To better
identify the regional and vessel‐specific spectrum of aneurysms in different subtypes of …