Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Uncoupling protein (UCP) 1 is an integral membrane protein that is located in the
mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a …

Maintenance of normal blood glucose levels depends on a complex interplay between the
insulin responsiveness of skeletal muscle and liver and glucose-stimulated insulin secretion …

ATP-sensitive potassium (KATP) channels, so named because they are inhibited by
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …

The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Despite our tendency to overeat, excessive fat accumulation was prevented in the past, as
any excess weight soon impaired the physical fitness required to gather food, and to either …

Summary Uncoupling protein 2 (UCP2) negatively regulates insulin secretion. UCP2
deficiency (by means of gene knockout) improves obesity-and high glucose-induced β cell …

Significance: Mitochondria are the energetic, metabolic, redox, and information signaling
centers of the cell. Substrate pressure, mitochondrial network dynamics, and cristae …

This is the tenth update of the human obesity gene map, incorporating published results up
to the end of October 2003 and continuing the previous format. Evidence from single‐gene …