Exosomes and ectosomes in intercellular communication

J Meldolesi - Current Biology, 2018 - cell.com
Exosomes and ectosomes, two distinct types of extracellular vesicles generated by all types
of cell, play key roles in intercellular communication. The formation of these vesicles …

Extracellular membrane vesicles in the three domains of life and beyond

S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …

Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications

C Han, J Yang, J Sun, G Qin - Pharmacology & therapeutics, 2022 - Elsevier
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …

Expansion of islet-resident macrophages leads to inflammation affecting β cell proliferation and function in obesity

W Ying, YS Lee, Y Dong, JS Seidman, M Yang, R Isaac… - Cell metabolism, 2019 - cell.com
The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

L Statello, M Maugeri, E Garre, M Nawaz, J Wahlgren… - PloS one, 2018 - journals.plos.org
The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA);
however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely …

Extracellular vesicles and matrix remodeling enzymes: the emerging roles in extracellular matrix remodeling, progression of diseases and tissue repair

M Nawaz, N Shah, BR Zanetti, M Maugeri, RN Silvestre… - Cells, 2018 - mdpi.com
Extracellular vesicles (EVs) are membrane enclosed micro-and nano-sized vesicles that are
secreted from almost every species, ranging from prokaryotes to eukaryotes, and from …

Lipid nanoparticles deliver the therapeutic VEGFA mRNA in vitro and in vivo and transform extracellular vesicles for their functional extensions

M Nawaz, S Heydarkhan‐Hagvall… - Advanced …, 2023 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID‐
19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF‐A …

Communication in the cancer microenvironment as a target for therapeutic interventions

A Dominiak, B Chełstowska, W Olejarz, G Nowicka - Cancers, 2020 - mdpi.com
The tumor microenvironment (TME) is a complex system composed of multiple cells, such as
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

A Sartori-Rupp, D Cordero Cervantes, A Pepe… - Nature …, 2019 - nature.com
The orchestration of intercellular communication is essential for multicellular organisms. One
mechanism by which cells communicate is through long, actin-rich membranous protrusions …

Stem cell‐derived extracellular vesicles as immunomodulatory therapeutics

Y Seo, HS Kim, IS Hong - Stem cells international, 2019 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on
immune cells which make them alternative therapeutics for the treatment of inflammatory …