Exposure to hostile conditions initiates responses organized to enhance the probability of
survival. These coordinated responses, known as stress responses, are composed of …

The subject of neuroinflammation is reviewed. In response to psychological stress or certain
physical stressors, an inflammatory process may occur by release of neuropeptides …

The localization of substance P in brain regions that coordinate stress responses and
receive convergent monoaminergic innervation suggested that substance P antagonists …

Substance P (SP) is one of the most abundant peptides in the central nervous system and
has been implicated in a variety of physiological and pathophysiological processes …

Increasing evidence implicates the substance P (SP)/neurokinin-1 receptor system in
anxiety and depression. However, it is not known whether emotional stimulation alters …

Massage‐like stroking induces acute antinociceptive effects that can be reversed by an
oxytocin antagonist, indicating activation of oxytocin on endogenous pain controlling …

The development of small-molecule antagonists of the substance P (SP)-preferring
tachykinin NK 1 receptor during the past decade represents an important opportunity to …

BACKGROUND: Evidence is accumulating that pharmacological blockade of the substance
P preferring neurokinin-1 (NK1) receptor reduces anxiety. This study compared the effects of …

Somatostatin (SST) is a cyclic polypeptide that inhibits the release of a variety of regulatory
hormones (eg growth hormone, insulin, glucagon, thyrotropin). Moreover, SST is widely …

The regulation of stress-induced vocalisations by central NK1 receptors was investigated
using pharmacological antagonists in guinea-pigs, a species with human-like NK1 …