Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
[HTML][HTML] Nebulised delivery of RNA formulations to the lungs: From aerosol to cytosol
MT Neary, LM Mulder, PS Kowalski… - Journal of Controlled …, 2024 - Elsevier
In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …
Engineering aspects of lipid-based delivery systems: In vivo gene delivery, safety criteria, and translation strategies
Defects in the genome cause genetic diseases and can be treated with gene therapy. Due to
the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials …
the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials …
High-throughput conventional and stealth cationic liposome synthesis using a chaotic advection-based microfluidic device combined with a centrifugal vacuum …
I Eş, LJ Montebugnoli, MFP Filippi… - Chemical Engineering …, 2020 - Elsevier
Microfluidics is an emerging technology that allows efficient mixing of fluids on the nanoliter
scale and has recently been employed for the production of lipid-based systems. In this …
scale and has recently been employed for the production of lipid-based systems. In this …
Effective cytocompatible nanovectors based on serine-derived gemini surfactants and monoolein for small interfering RNA delivery
C Costa, IS Oliveira, JPN Silva, SG Silva… - Journal of Colloid and …, 2021 - Elsevier
Non-viral gene therapy based on gene silencing with small interfering RNA (siRNA) has
attracted great interest over recent years. Among various types of cationic complexation …
attracted great interest over recent years. Among various types of cationic complexation …
The diffusion-driven microfluidic process to manufacture lipid-based nanotherapeutics with stealth properties for siRNA delivery
Our study investigated the manufacturing of lipid-based nanotherapeutics with stealth
properties for siRNA delivery by employing a diffusion-driven microfluidic process in one or …
properties for siRNA delivery by employing a diffusion-driven microfluidic process in one or …
Hybrid polymer/lipid vesicle synthesis: Association between cationic liposomes and lipoplexes with chondroitin sulfate
The association of cationic carriers with different anionic mucoadhesive biopolymers has
been widely explored as an alternative to improve their delivery routes and specific …
been widely explored as an alternative to improve their delivery routes and specific …
Biocompatible cationic lipoamino acids as counterions for oral administration of API-ionic liquids
Purpose The use of ionic liquids (ILs) in drug delivery has focused attention on non-toxic IL
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
counterions. Cationic lipids can be used to form ILs with weakly acidic drugs to enhance …
Nanoparticles as Gene Vectors in Tumor Therapy
E Triantafyllopoulou, O Kontogiannis… - … of Biomaterials for …, 2023 - Wiley Online Library
Cancer is a group of diseases characterized by the uncontrolled growth of abnormal cells. It
is the second leading cause of death globally. However, better prevention, screening, and …
is the second leading cause of death globally. However, better prevention, screening, and …
Bulk and Microfluidic Synthesis of Stealth and Cationic Liposomes for Gene Delivery Applications
LG de la Torre, ACSN Pessoa, BG de Carvalho… - DNA Vaccines: Methods …, 2021 - Springer
This chapter describes the synthesis of stealth and cationic liposomes and their
complexation with plasmid DNA to generate lipoplexes for gene delivery applications. Two …
complexation with plasmid DNA to generate lipoplexes for gene delivery applications. Two …