Highlights•Kinetic models integrate heterogeneous data to give metabolic engineering
insights.•Need accurate catalytic and allostery kinetic parameters for quality kinetic …

To counteract oxidative stress and reactive oxygen species (ROS), bacteria evolved various
mechanisms, primarily reducing ROS through antioxidant systems that utilize cofactor …

Cell metabolism is the biochemical machinery that provides energy and building blocks to
sustain life. Understanding its fine regulation is of pivotal relevance in several fields, from …

In contrast to stoichiometric-based models, the development of large-scale kinetic models of
metabolism has been hindered by the challenge of identifying kinetic parameter values and …

Mathematical modeling is an essential tool for the comprehensive understanding of cell
metabolism and its interactions with the environmental and process conditions. Recent …

Microbial cell factories face changing environments during industrial fermentations. Kinetic
metabolic models enable the simulation of the dynamic metabolic response to these …

Despite significant efforts and remarkable progress, the inference of signaling networks from
experimental data remains very challenging. The problem is particularly difficult when the …

In silico kinetic modeling is an essential tool for rationally designing metabolically
engineered organisms based on a system-level understanding of their regulatory …

The performance of model-based bioprocess optimizations depends on the accuracy of the
mathematical model. However, models of bioprocesses often have large uncertainty due to …

Cell-free production systems are increasingly used for the synthesis of industrially relevant
chemicals and biopharmaceuticals. Cell-free systems often utilize cell lysates, but …