Targeting and crossing the blood-brain barrier with extracellular vesicles
J Saint-Pol, F Gosselet, S Duban-Deweer, G Pottiez… - Cells, 2020 - mdpi.com
The blood–brain barrier (BBB) is one of the most complex and selective barriers in the
human organism. Its role is to protect the brain and preserve the homeostasis of the central …
human organism. Its role is to protect the brain and preserve the homeostasis of the central …
In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
[HTML][HTML] The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier
TP Buzhdygan, BJ DeOre, A Baldwin-Leclair… - Neurobiology of …, 2020 - Elsevier
As researchers across the globe have focused their attention on understanding SARS-CoV-
2, the picture that is emerging is that of a virus that has serious effects on the vasculature in …
2, the picture that is emerging is that of a virus that has serious effects on the vasculature in …
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
Astrocytes are critical components of the neurovascular unit that support blood-brain barrier
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …
(BBB) function. Pathological transformation of astrocytes to reactive states can be protective …
Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis
The restrictive nature of the blood–brain barrier (BBB) creates a major challenge for brain
drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular …
drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular …
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
Challenges in drug development of neurological diseases remain mainly ascribed to the
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …
blood–brain barrier (BBB). Despite the valuable contribution of animal models to drug …
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …
Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening
Efficient delivery of therapeutics across the neuroprotective blood–brain barrier (BBB)
remains a formidable challenge for central nervous system drug development. High‐fidelity …
remains a formidable challenge for central nervous system drug development. High‐fidelity …
A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier
The neurovascular unit is a complex, interdependent system composed of neurons and
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …