Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and
drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is …

Metabotropic glutamate receptor type 5 (mGluR5) upregulation in temporal lobe epilepsy
(TLE) and the correlation of its expression with features of hippocampal sclerosis (HS) …

In epilepsy patients, drug-resistant seizures often originate in one of the temporal lobes. In
selected cases, when certain requirements are met, this area is surgically resected for …

The proper functioning of the central nervous system (CNS) depends on the physiological
homeostasis, which is itself maintained and regulated by two opposite forces acting …

The group I metabotropic glutamate receptor 5 (mGluR5) has been implicated in the
pathology of various neurological disorders including schizophrenia, ADHD, and autism …

Objective A common rodent model in epilepsy research employs the muscarinic
acetylcholine receptor (m AC hR) agonist pilocarpine, yet the mechanisms underlying the …

Status epilepticus (SE) is associated with complex reorganization of hippocampal circuits
involving a significant loss of specific subtypes of GABAergic interneurons. While adaptive …

Precise detection of brain regions harboring heightened electrical activity plays a central
role in the understanding and treatment of diseases such as epilepsy. Superparamagnetic …

GABAergic interneurons in the hippocampus are critically involved in almost all
hippocampal circuit functions including coordinated network activity. Somatostatin …

Sexual differentiation of the brain is influenced by testosterone and its metabolites during the
perinatal period, when many aspects of brain development, including the maturation of …