Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Background Acute promyelocytic leukemia (APL) has a characteristic peculiar morphologic
and genetic features as well as a more favorable outcome. We studied the differential effect …

Detection of genetic mutations leading to hematological malignancies is a key factor in the
early diagnosis of acute myeloid leukemia (AML). FLT3-ITD mutations are an alarming gene …

Acute myeloid leukemia (AML) is an infrequent disease, and it is associated with high
morbidity and mortality. It harbors a unique configuration of cytogenetic abnormalities and …

Background: Adult acute leukemia most commonly manifests as acute myeloid leukemia
(AML), a highly heterogeneous malignant tumor of the blood system. The application of …

Abstract KLOPPERS, Jean F.; KOCK, André de; CRONJE, Johané and VAN MARLE, Anne-
Cecilia. Molecular characterisation of NPM1 and FLT3-ITD mutations in a central South …

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized
by the abnormal and rapid growth of cells. The mutation of the Fms-like tyrosine kinase 3 …

Epigenetic mechanisms are crucial for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Impaired epigenetic processes can cause …

De novo Acute Myeloid Leukemia is one of the diseases from which many people die each
year. It is the most common type of all types of cancer and causes death of people all over …

Myeloid neoplasms, especially acute myeloid leukemia (AML), are characterized by
abnormal proliferation of hematopoietic cells and by genomic instability with a high diversity …