The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …

There has been an increased understanding, over the past 2 decades, that asthma is a
chronic, immunologically mediated condition with a disturbance of the normal airway repair …

Asthma is a chronic inflammatory respiratory disease that affects over 300 million people
worldwide. Glucocorticoids are a mainstay therapy for asthma because they exert anti …

The pathogenesis of asthma includes a complex interplay among airway inflammation,
hyperresponsiveness, and remodeling. Current evidence suggests that airway structural …

Chronic obstructive pulmonary disease (COPD) and asthma are both associated with airflow
restriction and progressive remodeling, which affect the respiratory tract. Among various …

Epithelial cells of the lung are located at the interface between the environment and the
organism and serve many important functions including barrier protection, fluid balance …

The NF-κB pathway is central to the regulation of inflammation. Here, we demonstrate that
the low-output nitric oxide (NO) synthase 1 (NOS1 or nNOS) plays a critical role in the …

Rationale: Bronchial thermoplasty is an alternative treatment for patients with severe,
uncontrolled asthma in which the airway smooth muscle is eliminated using radioablation …

Lung function declines as people age and their lungs become stiffer. With an increasing
elderly population, understanding mechanisms that contribute to these structural and …

The asthma-obesity syndrome represents a major public health concern that
disproportionately contributes to asthma severity and induces insensitivity to therapy. To …