Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Abstract Three-dimensional (3D) printing has revolutionized the world manufacturing
production. In biomedical applications, however, 3D printed constructs fell short of …

The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

Cardiomyocytes from human pluripotent stem cells (hPSC-CM) have many potential
applications in disease modelling and drug target discovery but their phenotypic similarity to …

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in
engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart …

Here, we have developed a 3D bioprinted microchanneled gelatin hydrogel that promotes
human mesenchymal stem cell (hMSC) myocardial commitment and supports native …