Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

Novel imidazole-chalcone derivatives were designed and synthesized as tubulin
polymerization inhibitors and anticancer agents. The antiproliferative activity of the imidazole …

A new series of quinoline-chalcone hybrids was synthesized. The structures of these
compounds were characterized by spectroscopic methods including 1 H and 13 CNMR and …

A new series of styrylquinolines was designed and synthesized as anticancer agents and
tubulin polymerization inhibitors. The in vitro anticancer activity of the synthesized quinolines …

A series of naphthalene-chalcone derivatives (3a–3t) were prepared and evaluated as
tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were …

Background The carbazole skeleton is an important structural motif occurring naturally or
synthesized chemically and has antihistaminic, antioxidant, antitumor, antimicrobial, and anti …