Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the
accumulation of alpha-synuclein (aSyn) in the nigrostriatal pathway that is followed by …

Mitochondria are one of the essential cellular organelles. Apart from being considered as
the powerhouse of the cell, mitochondria have been widely known to regulate redox …

Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause
autosomal recessive early-onset Parkinson's disease (PD). Extensive in vitro and in vivo …

Abstract Defects in Coenzyme Q (CoQ) metabolism have been associated with primary
mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The …

The nervous system is the central hub of the body, detecting environmental and internal
stimuli to regulate organismal metabolism via communications to the peripheral tissues …

Parkinson's disease (PD) is a very common neurodegenerative disorder and is considered
to be one of the most severe disorders worldwide. Mutations in some PD causing genes are …

DNA methylation and hydroxymethylation have been implicated in the regulatory dynamics
of gene expression in normal development and differentiation. 5-Hydroxymethylcytosine …

Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD).
However, the identity and function of the most vulnerable DAN populations in prodromal PD …

Pesticides represent a serious problem for agricultural workers due to their neurotoxic
effects. The aim of this study was to evaluate the ability of pharmacological oxidative …