Advances and opportunities in RNA structure experimental determination and computational modeling

J Zhang, Y Fei, L Sun, QC Zhang - Nature methods, 2022 - nature.com
Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

Advances in RNA 3D structure modeling using experimental data

B Li, Y Cao, E Westhof, Z Miao - Frontiers in genetics, 2020 - frontiersin.org
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …

Visualizing RNA conformational and architectural heterogeneity in solution

J Ding, YT Lee, Y Bhandari, CD Schwieters… - Nature …, 2023 - nature.com
RNA flexibility is reflected in its heterogeneous conformation. Through direct visualization
using atomic force microscopy (AFM) and the adenosylcobalamin riboswitch aptamer …

Computational modeling of RNA 3D structure based on experimental data

A Ponce-Salvatierra, Astha, K Merdas… - Bioscience …, 2019 - portlandpress.com
RNA molecules are master regulators of cells. They are involved in a variety of molecular
processes: they transmit genetic information, sense cellular signals and communicate …

Advances, Applications, and Perspectives in Small‐Angle X‐ray Scattering of RNA

JN Tants, A Schlundt - Chembiochem, 2023 - Wiley Online Library
RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

Modeling, simulations, and bioinformatics at the service of RNA structure

PD Dans, D Gallego, A Balaceanu, L Darré, H Gómez… - Chem, 2019 - cell.com
Although chemically close to DNA, RNA can adopt a wide range of structures from regular
helices to complex globular conformations, showing a complexity similar to that of proteins …

[HTML][HTML] RNA structure determination: From 2D to 3D

J Deng, X Fang, L Huang, S Li, L Xu, K Ye, J Zhang… - Fundamental …, 2023 - Elsevier
RNA molecules serve a wide range of functions that are closely linked to their structures.
The basic structural units of RNA consist of single-and double-stranded regions. In order to …

Dynamic structural biology experiments at XFEL or synchrotron sources

P Aller, AM Orville - Structural Proteomics: High-Throughput Methods, 2021 - Springer
Macromolecular crystallography (MX) leverages the methods of physics and the language of
chemistry to reveal fundamental insights into biology. Often beautifully artistic images …

Sampling globally and locally correct rna 3d structures using ernwin, spqr and experimental saxs data

BC Thiel, G Bussi, S Poblete, IL Hofacker - bioRxiv, 2022 - biorxiv.org
The determination of the three-dimensional structure of large RNA macromolecules in
solution is a challenging task that often requires the use of several experimental and …

State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development

P Poltronieri, B Sun, KY Huang, TH Chang, TY Lee - Microrna, 2018 - ingentaconnect.com
Background: High-risk HPV subtypes are driving forces for human cancer development:
HPV-16 and HPV-18 are responsible for most HPV-caused cancers. Objective: This review …