Antibiotic use in early life disrupts microbial colonization and increases the risk of
developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …

Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …

Basal cells (BCs) are the progenitor cells responsible for tracheal epithelium integrity. Here,
we demonstrate that mitochondrial pyruvate carriers (MPCs) act as metabolic checkpoints …

While all eukaryotic cells are dependent on mitochondria for function, in a complex tissue,
which cell type and which cell behavior are more sensitive to mitochondrial deficiency …

A cell is a dynamic system in which various processes occur simultaneously. In particular,
intra-and intercellular signaling pathway crosstalk has a significant impact on a cell's life …

Formation of branched organs requires sequential differentiation of stem cells. In this work,
we find that the conducting airways derived from SOX2+ progenitors in the murine lungs fail …

Alveolar formation increases the surface area for gas exchange. A molecular understanding
of alveologenesis remains incomplete. Here, we show that the autonomic nerve and …

Adults born preterm have an increased risk of pulmonary vascular disease. Extreme preterm
infants often require supplemental oxygen but they also exhibit frequent intermittent …

Post-mitotic, non-proliferative dermal fibroblasts have crucial functions in maintenance and
restoration of tissue homeostasis. They are involved in essential processes such as wound …

Premature infants with bronchopulmonary dysplasia (BPD) have impaired alveolar gas
exchange due to alveolar simplification and dysmorphic pulmonary vasculature. Advances …