Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …

Objectives To describe the global trends of pulmonary nontuberculous mycobacteria (NTM)
infection and disease. Methods A systematic review of studies including culture-based NTM …

Synthetic biology holds great promise for addressing global needs. However, most current
developments are not immediately translatable to 'outside-the-lab'scenarios that differ from …

Highlights•Natural products contribute more than one-third of all FDA-approved NMEs.•The
absolute number of natural product approvals peaked in the 1990s and has since …

Background The cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …

BACKGROUND Gene and engineered-cell therapies promise new treatment modalities for
incurable or difficult-to-treat diseases. First-generation gene and engineered-cell therapies …

To transform developing and least developing countries into industrialised ones,
biotechnology could be deployed along the value chain, to provide support to the …

Half-maximal inhibitory concentration (IC 50) is the most widely used and informative
measure of a drug's efficacy. It indicates how much drug is needed to inhibit a biological …

Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …