Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

Metabolism of glycosphingolipids and their role in the pathophysiology of lysosomal storage disorders

AE Ryckman, I Brockhausen, JS Walia - International Journal of …, 2020 - mdpi.com
Glycosphingolipids (GSLs) are a specialized class of membrane lipids composed of a
ceramide backbone and a carbohydrate-rich head group. GSLs populate lipid rafts of the …

Functions of sphingolipids in pathogenesis during host–pathogen interactions

J Wang, YL Chen, YK Li, DK Chen, JF He… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

Comparative molecular and immunoregulatory analysis of extracellular vesicles from Candida albicans and Candida auris

D Zamith-Miranda, HM Heyman, SP Couvillion… - Msystems, 2021 - Am Soc Microbiol
Candida auris is a recently described multidrug-resistant pathogenic fungus that is
increasingly responsible for health care-associated outbreaks across the world …

Analysis of sphingolipids, sterols, and phospholipids in human pathogenic Cryptococcus strains [S]

A Singh, A MacKenzie, G Girnun, M Del Poeta - Journal of lipid research, 2017 - ASBMB
Cryptococcus species cause invasive infections in humans. Lipids play an important role in
the progression of these infections. Independent studies done by our group and others …

Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans

ST Denham, JCS Brown - Journal of Fungi, 2018 - mdpi.com
Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens

M Sertbas, KO Ulgen - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

Acylhydrazones as antifungal agents targeting the synthesis of fungal sphingolipids

C Lazzarini, K Haranahalli, R Rieger… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The incidence of invasive fungal infections has risen dramatically in recent decades. Current
antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum …

Peeling the onion: the outer layers of Cryptococcus neoformans

DP Agustinho, LC Miller, LX Li… - Memórias do Instituto …, 2018 - SciELO Brasil
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the
environment. It causes a deadly meningitis that is responsible for over 180,000 deaths …

Antifungal drug development: targeting the fungal sphingolipid pathway

K McEvoy, TG Normile, M Del Poeta - Journal of Fungi, 2020 - mdpi.com
Fungal infections are becoming more prevalent and problematic due to the continual rise of
immune deficient patients as well as the progressive development of drug resistance …