Background Congenital disorders of glycosylation (CDG) are inherited metabolic diseases
caused by defects in the genes important for the process of protein and lipid glycosylation …

The Golgi apparatus is known to underpin many important cellular homeostatic functions,
including trafficking, sorting and modifications of proteins or lipids. These functions are …

The development of the musculoskeletal system is a complex process that involves very
precise control of bone formation and growth as well as remodeling during postnatal life …

Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

Introduction The eukaryotic cell contains membrane-bound organelles with distinct
functionality and composition. Preservation of organelle identity depends on the highly …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

A number of long coiled-coil proteins are present on the Golgi. Often referred to as “golgins,”
they are well conserved in evolution and at least five are likely to have been present in the …

The Golgi apparatus lies at the centre of the secretory pathway. It consists of a series of
flattened compartments typically organised into a stack that, in mammals, is connected to …

In addition to the classical functions of the Golgi in membrane transport and glycosylation,
the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of …

Paget's disease of bone (PDB) is a common disorder characterized by focal abnormalities of
bone remodeling. We previously identified variants at the CSF1, OPTN and TNFRSF11A loci …