Treatment options for motor and non-motor symptoms of Parkinson's disease

FC Church - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) usually presents in older adults and typically has both motor and
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …

Orthostatic hypotension: Review and expert position statement

E Vidal-Petiot, A Pathak, JP Azulay, A Pavy-Le Traon… - Revue …, 2024 - Elsevier
Orthostatic hypotension is defined as a drop in systolic blood pressure of at least 20 mmHg
or a drop in diastolic blood pressure of at least 10 mmHg within 3 minutes of standing. It is a …

Mismatch between subjective and objective dysautonomia

P Novak, DM Systrom, SP Marciano, A Knief… - Scientific Reports, 2024 - nature.com
Autonomic symptom questionnaires are frequently used to assess dysautonomia. It is
unknown whether subjective dysautonomia obtained from autonomic questionnaires …

Baroreflex-sympathoneural without baroreflex-cardiovagal failure in neurogenic orthostatic hypotension

DS Goldstein, S Dill, P Sullivan, E Grabov… - Clinical Autonomic …, 2023 - Springer
We describe a patient with neurogenic orthostatic hypotension (nOH) after brainstem
neurosurgery in whom baroreflex-cardiovagal function was normal despite baroreflex …

Pathophysiology of syncope: current concepts and their development

DG Benditt, A Fedorowski, R Sutton… - Physiological …, 2025 - journals.physiology.org
Syncope is a symptom in which transient loss of consciousness occurs as a consequence of
a self-limited, spontaneously terminating period of cerebral hypoperfusion. Many circulatory …

Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions

BL Chen, W Yang, Y Luo, EK Tan, Q Wang - Journal of Neurology, 2023 - Springer
Multiple system atrophy (MSA) is a sporadic, fatal, and rapidly progressive
neurodegenerative disease of unknown etiology that is clinically characterized by autonomic …

Longitudinal prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative (PPMI) cohort

P Beach, JL McKay - Autonomic Neuroscience, 2024 - Elsevier
Background Reported orthostatic hypotension (OH) prevalence in Parkinson's disease (PD)
varies widely, with few studies evaluating specifically neurogenic-OH (nOH). The ratio of …

Orthostatic hypotension with nondipping: phenotype of neurodegenerative disease

M Nagai, M Kato, K Dote - Hypertension Research, 2022 - nature.com
More than 40 years ago, Jim Rafterry and his group at Northwick Park Hospital in London
and John Floras and Peters Sleight at John Radcliffe Hospital in Oxford conducted a series …

Pronounced orthostatic hypotension in GBA-related Parkinson's disease

T Usnich, H Hanssen, K Lohmann… - Journal of …, 2022 - content.iospress.com
Patients with Parkinson's disease (PD) carrying variants in the Glucocerebrosidase (GBA)
gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients …

[HTML][HTML] Neurogenic Orthostatic Hypotension in Parkinson Disease—A Narrative Review of Diagnosis and Management

C Grosu, O Noea, A Maștaleru, EB Ignat… - Journal of Clinical …, 2025 - mdpi.com
Background: Neurogenic orthostatic hypotension (NOH) is a significant non-motor
manifestation of Parkinson's disease (PD), that substantially affects patient disability and has …