Context: Continuous processing is an innovative production concept well known and
successfully used in other industries for many years. The modern pharmaceutical industry is …

Residence time distribution (RTD) models are essential to understand process dynamics
and support process monitoring and control in continuous manufacturing systems. RTD …

The discrete element method (DEM) typically uses an explicit numerical integration scheme
to solve the equations of motion. However, like all explicit schemes, the scheme is only …

Residence time distribution (RTD) modeling can aid the understanding and characterization
of macro-mixing in continuous powder processing unit operations by relating observed …

Continuous powder blending is an essential operation during continuous pharmaceutical
manufacturing. However, the complex granular dynamics in the blender is still poorly …

This study focuses on the twin screw granulator of a continuous from-powder-to-tablet
production line. Whereas powder dosing into the granulation unit is possible from a …

In this study, an integrated flowsheet model of the continuous feeder-mixer system was
calibrated, simulated and compared against experimental data. The feeding process was …

Parts of Chapters have been published within a book chapter titled: Process simulation and
control for continuous pharmaceutical manufacturing of solid drug products. The chapter …

针对高分子复合材料粉体混合均匀性和工艺可重现性难以调控的行业共性技术瓶颈,
模拟研究了粉体混合均匀性和工艺可重现性相对标准偏差(RSD) 与入口粉体配方比的组分含量 …

The large data sets obtained in real-time monitoring of batch and continuous manufacturing
processes require statistical methods to extract information on the state of critical process …