Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

BACKGROUND Classic embryological studies showed that diffusible factors (morphogens)
influence cell fate during dorsal-ventral (DV) axis patterning. Subsequently, mathematical …

Secreted signals, known as morphogens, provide the positional information that organizes
gene expression and cellular differentiation in many developing tissues. In the vertebrate …

Pax genes encode a family of transcription factors that orchestrate complex processes of
lineage determination in the developing embryo. Their key role is to specify and maintain …

In many developing tissues, the patterns of gene expression that assign cell fate are
organized by graded secreted signals. Cis-regulatory elements (CREs) interpret these …

Systems biology seeks not only to discover the machinery of life but to understand how such
machinery is used for control, ie, for regulation that achieves or maintains a desired, useful …

In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a
characteristic pattern of gene expression. Here we quantify the Shh gradient in the …

Sharply delineated domains of cell types arise in developing tissues under instruction of
inductive signal (morphogen) gradients, which specify distinct cell fates at different signal …

Successful infection strategies must balance pathogen amplification and persistence. In the
obligate intracellular parasite Toxoplasma gondii this is accomplished through differentiation …