Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20
years ago. Since that time, phosphine probes have been used in myriad applications to tag …

Base‐modified fluorescent nucleoside analog probes have been very valuable in the study
of nucleic acid structure and function. Many of them structurally resemble natural bases, and …

Cellular RNA labeling strategies based on bioorthogonal chemical reactions are much less
developed in comparison to glycan, protein and DNA due to its inherent instability and lack …

We present a chemo-enzymatic approach for site-specific labeling of 5′-capped RNAs
based on bioorthogonal chemistry. A trimethylguanosine synthase was engineered to …

Real‐time tracking of RNA expression can provide insight into the mechanisms used to
generate cellular diversity, as well as help determine the underlying causes of disease. Here …

The eukaryotic cell is highly complex. Ever since Robert Hooke discovered “cells” in 1665
when training his comparably primitive microscope on a sliver of cork, scientists have aimed …

Pd-catalyzed CC bond formation, an important vertebra in the spine of synthetic chemistry, is
emerging as a valuable chemoselective transformation for post-synthetic functionalization of …

Reactive RNA probes are useful for studying and identifying RNA‐binding proteins. To that
end, we designed and synthesized chloroacetamide‐linked 7‐deaza‐ATP which was a …

To understand the structure and ensuing function of RNA in various cellular processes,
researchers greatly rely on traditional as well as contemporary labeling technologies to …

5-Azidomethyl dUTP and two 5-trans-cyclooctene dUTPs with different linkers between the
TCO and the uracil base have been incorporated into DNA by primer extension, reverse …