The magic of bicelles lights up membrane protein structure

UHN Dürr, M Gildenberg, A Ramamoorthy - Chemical reviews, 2012 - ACS Publications
Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

[HTML][HTML] Choosing membrane mimetics for NMR structural studies of transmembrane proteins

DE Warschawski, AA Arnold, M Beaugrand… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy

B Bechinger, ES Salnikov - Chemistry and physics of lipids, 2012 - Elsevier
Solid-state NMR spectroscopic techniques provide valuable information about the structure,
dynamics and topology of membrane-inserted polypeptides. In particular antimicrobial …

Recent advances in the application of solution NMR spectroscopy to multi-span integral membrane proteins

HJ Kim, SC Howell, WD Van Horn, YH Jeon… - Progress in nuclear …, 2009 - Elsevier
Roughly one-third of all proteins reside in biological membranes [1, 2]. Integral membrane
proteins (IMPs), which can only be released from the membrane by disruption of the …

[HTML][HTML] Solution NMR of membrane proteins in bilayer mimics: small is beautiful, but sometimes bigger is better

SF Poget, ME Girvin - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2007 - Elsevier
Considerable progress has been made recently on solution NMR studies of multi-
transmembrane helix membrane protein systems of increasing size. Careful correlation of …

[HTML][HTML] The cytochromes P450 and b5 and their reductases—promising targets for structural studies by advanced solid-state NMR spectroscopy

UHN Dürr, L Waskell, A Ramamoorthy - Biochimica et Biophysica Acta …, 2007 - Elsevier
Members of the cytochrome P450 (cyt P450) superfamily of enzymes oxidize a wide array of
endogenous and xenobiotic substances to prepare them for excretion. Most of the drugs in …

[HTML][HTML] Moderate and strong static magnetic fields directly affect EGFR kinase domain orientation to inhibit cancer cell proliferation

L Zhang, J Wang, HL Wang, W Wang, Z Li, J Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Static magnetic fields (SMFs) can affect cell proliferation in a cell-type and intensity-
dependent way but the mechanism remains unclear. At the same time, although the …

[HTML][HTML] Effects of lipid chain length and unsaturation on bicelles stability. A phosphorus NMR study

MN Triba, PF Devaux, DE Warschawski - Biophysical journal, 2006 - cell.com
Most studies reported until now on the magnetically alignable system formed by the binary
mixtures of long-and short-chain lipids were based on the mixture of 1, 2-dimyristoyl-sn …

Bicelles and other membrane mimics: comparison of structure, properties, and dynamics from MD simulations

M Vestergaard, JF Kraft, T Vosegaard… - The Journal of …, 2015 - ACS Publications
The increased interest in studying membrane proteins has led to the development of new
membrane mimics such as bicelles and nanodiscs. However, only limited knowledge is …

Opsin stability and folding: modulation by phospholipid bicelles

C McKibbin, NA Farmer, C Jeans, PJ Reeves… - Journal of molecular …, 2007 - Elsevier
Integral membrane proteins do not fare well when extracted from biological membranes and
are unstable or lose activity in detergents commonly used for structure and function …