Innate immunity activation in the early brain injury period following subarachnoid hemorrhage

T Gris, P Laplante, P Thebault, R Cayrol… - Journal of …, 2019 - Springer
Background Aneurysmal subarachnoid hemorrhage (SAH) is a catastrophic disease with
devastating consequences, including a high mortality rate and severe disabilities among …

Precision health for Chagas disease: integrating parasite and host factors to predict outcome of infection and response to therapy

SJ Martinez, PS Romano, DM Engman - Frontiers in Cellular and …, 2020 - frontiersin.org
Chagas disease, caused by the infection with the protozoan parasite Trypanosoma cruzi, is
clinically manifested in approximately one-third of infected people by inflammatory heart …

New insights into Trypanosoma cruzi genetic diversity, and its influence on parasite biology and clinical outcomes

MMA Silvestrini, GD Alessio, BED Frias… - Frontiers in …, 2024 - frontiersin.org
Chagas disease, caused by Trypanosoma cruzi, remains a serious public health problem
worldwide. The parasite was subdivided into six distinct genetic groups, called “discrete …

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease

I Carrillo, RAN Rabelo, C Barbosa… - PLoS Neglected …, 2021 - journals.plos.org
Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in
Latin America and is widely distributed worldwide because of migration. In 30% of cases …

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity

ML Sykes, EK Kennedy, VM Avery - Microorganisms, 2023 - mdpi.com
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The
disease causes~ 12,000 deaths annually and is one of the world's 20 neglected tropical …

Gold‐Enhanced Brachytherapy by a Nanoparticle‐Releasing Hydrogel and 3D‐Printed Subcutaneous Radioactive Implant Approach

M Kiseleva, T Lescot, SV Selivanova… - Advanced Healthcare …, 2023 - Wiley Online Library
Brachytherapy (BT) is a widely used clinical procedure for localized cervical cancer
treatment. In addition, gold nanoparticles (AuNPs) have been demonstrated as powerful …

Differential activation of splenic cDC1 and cDC2 cell subsets following poxvirus infection of BALB/c and C57BL/6 mice

L Szulc-Dąbrowska, Z Biernacka, M Koper, J Struzik… - Cells, 2023 - mdpi.com
Conventional dendritic cells (cDCs) are innate immune cells that play a pivotal role in
inducing antiviral adaptive immune responses due to their extraordinary ability to prime and …

Vaccination with Mincle agonist UM-1098 and mycobacterial antigens induces protective Th1 and Th17 responses

V Rungelrath, M Ahmed, L Hicks, SM Miller, KT Ryter… - npj Vaccines, 2024 - nature.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the top infectious
killers in the world. The only licensed vaccine against TB, Bacille Calmette-Guérin (BCG) …

A murine model of dengue virus infection in suckling C57BL/6 and BALB/c mice

AB Byrne, AG García, JM Brahamian… - Animal Models and …, 2021 - Wiley Online Library
Dengue is a significant public health concern across tropical and subtropical regions
worldwide, principally causing disease in children. Very young children are at increased risk …

Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi

DM Medina-Buelvas, M Rodríguez-Sosa, L Vega - Pathogens, 2021 - mdpi.com
Macrophages (MΦ) play a key role in the development of the protective immune response
against Trypanosoma cruzi infection. To determine the role of MΦ subtypes M1 and M2 in …