DNA double-strand breaks (DSBs) are critical lesions that can result in cell death or a wide
variety of genetic alterations including large-or small-scale deletions, loss of heterozygosity …

The process of homologous recombinational repair (HRR) is a major DNA repair pathway
that acts on double-strand breaks and interstrand crosslinks, and probably to a lesser extent …

In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous
and nonhomologous mechanisms. By definition, homologous recombination requires a …

Long interspersed element-1 (L1) is an autonomous retroelement that is active in the human
genome. The proposed mechanism of insertion for L1 suggests that cleavage of both …

The complex allotetraploid genome is one of major challenges in cotton for repressing gene
expression. Developing site-specific DNA mutation is the long-term dream for cotton …

Mutation of BRCA2 causes familial early onset breast and ovarian cancer. BRCA2 has been
suggested to be important for the maintenance of genome integrity and to have a role in …

Gene targeting in mammalian cells has proven invaluable in biotechnology, in studies of
gene structure and function, and in understanding chromosome dynamics. It also offers a …

53BP1 participates early in the DNA damage response and is involved in cell cycle
checkpoint control. Moreover, the phenotype of mice and cells deficient in 53BP1 suggests a …

In mammalian cells, the repair of DNA double-strand breaks (DSBs) occurs by both
homologous and non-homologous mechanisms. Indirect evidence, including that from gene …

The tumor suppressor gene BRCA1 was cloned in 1994 based on its linkage to early-onset
breast and ovarian cancer. Although the BRCA1 protein has been implicated in multiple …