Figure 2. Physiopathological mechanisms of restenosis after experimental balloon injuries.
Representative histological crosssections. Common carotid artery from (A) normal rat (no …

Entry into and progression of vascular cells through the cell cycle is considered a key event
in vascular proliferative diseases. Multiple growth factors and cytokines have been found to …

Mechanisms controlling vascular smooth muscle cell (VSMC) plasticity and renewal still
remain to be elucidated completely. A class of small RNAs called microRNAs (miRs) …

Vascular gene transfer potentially offers new treatments for cardiovascular diseases. It can
be used to overexpress therapeutically important proteins and correct genetic defects, and to …

Human gene therapy (HGT) is defined as the transfer of nucleic acids (DNA) to somatic cells
of a patient which results in a therapeutic effect, by either correcting genetic defects or by …

Background—Vascular cells have a finite cell lifespan and eventually enter an irreversible
growth arrest, cellular senescence. The functional changes associated with cellular …

Substantial evidence exists supporting a direct role for raf kinases in the development and
maintenance of certain human malignancies. Here we test the potential of phosphorothioate …

Previous studies have shown that mitofusin 2 (Mfn-2)(or hyperplasia suppressor gene
[HSG]) inhibits vascular smooth muscle cell (VSMC) proliferation. Here, we demonstrate that …

Insulin maintains vascular smooth muscle cell (VSMC) quiescence yet can also promote
VSMC migration. The mechanisms by which insulin exerts these contrasting effects were …

3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA-reductase) inhibitors,
otherwise known as statins, are currently the medical treatment of choice for …