Unveiling the Multifaceted Roles of ISG15: From Immunomodulation to Therapeutic Frontiers
The Interferon Stimulated Gene 15 (ISG15), a unique Ubiquitin-like (Ubl) modifier exclusive
to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon …
to vertebrates, plays a crucial role in the immune system. Primarily induced by interferon …
Differential expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Alzheimer's disease and HIV-1 associated neurocognitive disorders
A Garces, B Martinez, R De La Garza, D Roy… - Scientific reports, 2023 - nature.com
Abstract The United Nations projects that one in every six people will be over the age of 65
by the year 2050. With a rapidly aging population, the risk of Alzheimer's disease (AD) …
by the year 2050. With a rapidly aging population, the risk of Alzheimer's disease (AD) …
Interferon‑stimulated gene 15 promotes progression of endometrial carcinoma and weakens antitumor immune response
X Zhao, J Wang, Y Wang, M Zhang… - Oncology …, 2022 - spandidos-publications.com
Endometrial carcinoma (EC) is one of the most common gynecological cancers with a poor
prognosis. Therefore, clarifying the details of the molecular mechanisms is of great …
prognosis. Therefore, clarifying the details of the molecular mechanisms is of great …
An MVA-based vector expressing cell-free ISG15 increases IFN-I production and improves HIV-1-specific CD8 T cell immune responses
M Falqui, B Perdiguero, R Coloma, M Albert… - Frontiers in Cellular …, 2023 - frontiersin.org
The human immunodeficiency virus (HIV), responsible of the Acquired Immune Deficiency
Syndrome (AIDS), continues to be a major global public health issue with any cure or …
Syndrome (AIDS), continues to be a major global public health issue with any cure or …
Immunogenicity and efficacy of a novel multi-patch SARS-CoV-2/COVID-19 vaccine candidate
B Perdiguero, L Marcos-Villar, M López-Bravo… - Frontiers in …, 2023 - frontiersin.org
Introduction While there has been considerable progress in the development of vaccines
against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has …
against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has …
ISG15–LFA1 interactions in latent HIV clearance: mechanistic implications in designing antiviral therapies
PS Koka, B Ramdass - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Interferon types-I/II (IFN-αβ/γ) secretions are well-established antiviral host defenses. The
human immunodeficiency virus (HIV) particles are known to prevail following targeted …
human immunodeficiency virus (HIV) particles are known to prevail following targeted …
Stem cell-derived viral antigen-specific T cells suppress HIV replication and PD-1 expression on CD4+ T cells
The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent
stem cells (PSCs), ie, PSC-CTLs, have the ability to suppress the human immunodeficiency …
stem cells (PSCs), ie, PSC-CTLs, have the ability to suppress the human immunodeficiency …
A IFI27 gene contributes to ER-stress mediated apoptosis and benefits for white spot syndrome virus infection in Litopenaeus vannamei
JQ Fan, YT Miao, KC Lu, G Chen, BB Li… - Fish & Shellfish …, 2022 - Elsevier
The interplay between virus and host has been one of the hot spot in virology, and it is also
the important aspect of revealing the mechanism of virus infection. Increasing studies …
the important aspect of revealing the mechanism of virus infection. Increasing studies …
Characterization of Biomarkers for Alzheimer's Disease and HIV-1 Associated Neurocognitive Disorders
A Garces III - 2021 - search.proquest.com
Alzheimer's disease is a neurodegenerative disorder that is characterized by progressive
cognitive decline and the accumulation of amyloid beta and neurofibrillary tangles in regions …
cognitive decline and the accumulation of amyloid beta and neurofibrillary tangles in regions …